Ulinastatin ameliorates LPS-induced pulmonary inflammation and injury by blocking the MAPK/NF-kappaB signaling pathways in rats.
RatEndotoxin/LPSSprague-DawleyMale
Model: Acute lung injury induced by intratracheal instillation of lipopolysaccharide 5 mg/kg
Ulinastatin attenuated lipopolysaccharide-induced lung injury, improving histological changes and reducing the lung wet/dry ratio, myeloperoxidase activity and Evans blue extravasation. Bronchoalveolar lavage pro-inflammatory cytokines and cell counts were reduced, and MAPK and NF-kappaB activation…
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