Propranolol attenuates cognitive, learning, and memory deficits in a murine model of traumatic brain injury.
MouseTBIControlled cortical impactC57BLMalen = 20 male mice, 10 per groupIntraperitoneal4 mg/kgFirst dose two hours after traumatic brain injury
Model: Controlled cortical impact producing moderate traumatic brain injury
Propranolol-treated mice had significantly higher novel object recognition scores than placebo at day 2 and completed the maze test faster from day 4 onwards. Serum IL-1beta, IL-6 and TNF-alpha did not differ. Treated animals had lower brain UCHL-1, higher Hsp-70 and fewer apoptotic neurons in the…
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