Intranasally Administered Exosomes from Umbilical Cord Stem Cells Have Preventive Neuroprotective Effects and Contribute to Functional Recovery after Perinatal Brain Injury.
RatTBIUnspecifiedWistarn = Morris water maze groups of approximately 8 to 14 animals p…IntranasalAdministered after induction of inflammation and prior to ischaemia, which was…
Model: Perinatal brain injury induced by intraperitoneal lipopolysaccharide followed by left common carotid artery occlusion and hypoxia (8 percent oxygen)
Intranasal mesenchymal stromal cell exosomes reduced neuron specific cell death, restored myelination and mature oligodendroglial and neuronal cell counts, and improved learning in the Morris water maze four weeks after injury.
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