THERAPY DOSSIER · th-b0319b96469d

Exosomes isolated from human Wharton's jelly mesenchymal stromal cells

Biologic · Exosomes from human Wharton's-jelly mesenchymal stromal cells; extracellular-vesicle biologic.

Evidence & regulatory context

Mechanism: Exosomes from human Wharton's-jelly mesenchymal stromal cells; extracellular-vesicle biologic.
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05413148 ↗PHASE2/PHASE3unknown

Wharton Jelly MSC and Stem Cell Exosomes on Visual Functions in Retinitis Pigmentosa

Retinitis Pigmentosa

Enrolment: 135 · Results not recorded

NCT06812637 ↗PHASE1completed

Wharton's Jelly MSC-Derived Exosomes for Diabetic Foot Ulcers

Diabetic Foot Ulcer

Enrolment: 110 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31398924 ↗2019Reported benefit

Intranasally Administered Exosomes from Umbilical Cord Stem Cells Have Preventive Neuroprotective Effects and Contribute to Functional Recovery after Perinatal Brain Injury.

RatTBIUnspecifiedWistarn = Morris water maze groups of approximately 8 to 14 animals p…IntranasalAdministered after induction of inflammation and prior to ischaemia, which was…

Model: Perinatal brain injury induced by intraperitoneal lipopolysaccharide followed by left common carotid artery occlusion and hypoxia (8 percent oxygen)

Intranasal mesenchymal stromal cell exosomes reduced neuron specific cell death, restored myelination and mature oligodendroglial and neuronal cell counts, and improved learning in the Morris water maze four weeks after injury.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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