Differentiation of human adipose-derived stem cells into neuron/motoneuron-like cells for cell replacement therapy of spinal cord injury.
MouseSpinal cord injuryCompressionC57BL/6Transplantation into the injured spinal cord1 x 10^6 cells
Model: Thoracic (T8) spinal cord crush injury
Grafted motoneuron-like cells survived, migrated and became electrophysiologically active, reduced cavity formation and inflammation, and produced partial locomotor recovery that relapsed when the graft was ablated with ganciclovir.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.