Autologous adipose mesenchymal stem cell transplantation for facial and auditory nerve dysfunction after microvascular decompression
Facial Nerve Injury
Enrolment: 100 · Results not recorded
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Biologic · Cell therapy: human ADSCs pre-differentiated with retinoic acid and sonic hedgehog toward a motoneuron-like phenotype; no ChEMBL entity. FLAGGED: no trial of pre-differentiated motoneuron-like ADSCs exists. The 3 retained trials use UNDIFFERENTIATED autologous adipose-derived stem or regenerative cells in peripheral nerve indications - platform-level evidence with a different cell state, needs manual review. Buccal fat pad, nano-fat and amniotic-membrane composite studies were excluded as different products.
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Facial Nerve Injury
Enrolment: 100 · Results not recorded
Retinal Degeneration · Primary Open-Angle Glaucoma
Enrolment: 16 · Results not recorded
Neurotmesis of Peripheral Nerve
Enrolment: 6 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Thoracic (T8) spinal cord crush injury
Grafted motoneuron-like cells survived, migrated and became electrophysiologically active, reduced cavity formation and inflammation, and produced partial locomotor recovery that relapsed when the graft was ablated with ganciclovir.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.