Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing.
RatOtherSprague-DawleyFemaleIntra-articular injectionAfter surgical induction of joint instability
Model: Surgically induced joint instability by anterior cruciate ligament transection plus partial medial meniscectomy
Bolus triamcinolone acetonide increased joint instability in about half of joints without altering cartilage degeneration, whereas sustained microsphere release increased instability in 94 percent of animals and caused dystrophic calcification and worse cartilage degeneration, with no effect in hea…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.