THERAPY DOSSIER · th-68874bd0f9cd

Triamcinolone acetonide, as a bolus or released from polyesteramide microspheres

Drug · Glucocorticoid receptor agonist

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Glucocorticoid receptor agonist
Target: Glucocorticoid receptor (CHEMBL2034)
Injury models: Other
Reported indication: Not recorded
First approval: 1960
Development stage: Not recorded
ChEMBL record: CHEMBL1504 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Triamcinolone acetonide; Kenalog; Aristocort; Nasacort; Zilretta; Triesence
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05844618 ↗PHASE4completed

Triamcinolone Acetonide (Aristocort C) in Atopic Dermatitis

Atopic Dermatitis

Enrolment: 20 · Results not recorded

NCT01570985 ↗PHASE3unknown

Corticosteroid (Triamcinolone Acetonide) With/Without Distension in Frozen Shoulder

Shoulder Adhesive Capsulitis · Frozen Shoulder

Enrolment: 120 · Results not recorded

NCT01095809 ↗PHASE3terminated

Intravitreous Bevacizumab Versus Triamcinolone Acetonide in Uveitic Macular Oedema

Uveitis

Enrolment: 5 · Results not recorded

NCT06977568 ↗PHASE2terminated

Intra-Articular ZILRETTA Versus Triamcinolone Acetonide IR in Osteoarthritis of the Hip

Osteoarthritis of Hip

Enrolment: 1 · Results not recorded

NCT05429450 ↗PHASE2completed

Periocular Methotrexate Versus Periocular Triamcinolone in Thyroid Associated Orbitopathy

Thyroid Associated Orbitopathy

Enrolment: 18 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31378925 ↗2019Reported harm

Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing.

RatOtherSprague-DawleyFemaleIntra-articular injectionAfter surgical induction of joint instability

Model: Surgically induced joint instability by anterior cruciate ligament transection plus partial medial meniscectomy

Bolus triamcinolone acetonide increased joint instability in about half of joints without altering cartilage degeneration, whereas sustained microsphere release increased instability in 94 percent of animals and caused dystrophic calcification and worse cartilage degeneration, with no effect in hea…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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