Dexmedetomidine protects against lung injury induced by limb ischemia-reperfusion via the TLR4/MyD88/NF-kB pathway.
RatIschaemia-reperfusionLimb / skeletal muscleSprague-DawleyMalen = n = 7 per group, four groups, 28 rats in totalIntraperitonealDexmedetomidine 25 microg/kg; atipamezole 250 microg/kg in…0.5 hour prior to ischaemia (preconditioning); atipamezole given before dexmede…
Model: Hind limb ischaemia-reperfusion: femoral artery clamped with a non-invasive arterial clip and ligated with rubber bands for 3 hours of ischaemia, followed by 2 hours of reperfusion, producing acute lung injury
Dexmedetomidine preconditioning significantly reduced lung oedema, histological injury, myeloperoxidase activity and BALF and serum IL-1, IL-6 and TNF-alpha relative to ischaemia-reperfusion alone, and lowered TLR4, MyD88, NF-kB and phosphorylated NF-kB expression. Atipamezole partially reversed th…
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