Neurons-derived extracellular vesicles promote neural differentiation of ADSCs: a model to prevent peripheral nerve degeneration.
MouseOtherFVBBoth sexes used, not separatedn = 28 FVB mice divided into three in vivo groups plus 3 donor…Local application to the nerve injury siteCells suspended in 5 microL of PBS; the exact cell number w…Immediately at the time of injury, during the same surgical procedure
Model: Sciatic nerve neurotmesis: the right sciatic nerve was exposed and cut, with analysis at 14 days after surgery
Sciatic Functional Index scores were numerically better in the neuron-like cell group at days 3, 7 and 10 but the authors report no statistical difference. Gastrocnemius wet weight, nerve diameter and nerve fibre area did not differ between groups. Axon density differed significantly between the ne…
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