THERAPY DOSSIER · th-f3a41b6e6a83

Adipose-derived stem cells co-cultured with neurons for 7 days (neuron-like cells, ADSC-CC D7, luciferin/GFP positive)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31371742 ↗2019Mixed findings

Neurons-derived extracellular vesicles promote neural differentiation of ADSCs: a model to prevent peripheral nerve degeneration.

MouseOtherFVBBoth sexes used, not separatedn = 28 FVB mice divided into three in vivo groups plus 3 donor…Local application to the nerve injury siteCells suspended in 5 microL of PBS; the exact cell number w…Immediately at the time of injury, during the same surgical procedure

Model: Sciatic nerve neurotmesis: the right sciatic nerve was exposed and cut, with analysis at 14 days after surgery

Sciatic Functional Index scores were numerically better in the neuron-like cell group at days 3, 7 and 10 but the authors report no statistical difference. Gastrocnemius wet weight, nerve diameter and nerve fibre area did not differ between groups. Axon density differed significantly between the ne…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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