Ameliorative effects of N-acetyl cysteine on diclofenac-induced renal injury in male rats based on serum biochemical parameters, oxidative biomarkers, and histopathological study.
RatChemical/toxinWistarMalen = Four groups; n per group not stated
Model: Diclofenac-induced nephrotoxicity in rats
Diclofenac significantly raised serum uric acid, TNF-alpha, creatinine, urea, GOT, GPT, protein carbonyl and malondialdehyde and renal TNF-alpha gene expression relative to control. N-acetyl cysteine and silymarin both significantly reduced these markers, and N-acetyl cysteine also reduced diclofen…
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