Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury.
Model: Moderate contusion spinal cord injury (70 kdyn) at the 9th thoracic level using an Infinite Horizons Impactor under pentobarbital anaesthesia (75 mg/kg intraperitoneally); separate experiments injected packed or lysed red blood cells or haem solution (125 or 250 microM, 2 microL at 1 microL/min) into naive spinal cord at T9
Tranexamic acid given immediately after contusion spinal cord injury significantly reduced intralesional red blood cell volume, bleeding area, haem content and demyelinated area compared with saline, whereas heparin worsened these measures. Tranexamic acid also reduced TLR4, TNF, MyD88 and NF-kB p6…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.