Promising role of filgrastim and alpha-tocopherol succinate in amelioration of gastrointestinal acute radiation syndrome (GI-ARS) in mice.
MouseRadiationMalen = Mice randomly allocated into 5 groups; group sizes not stat…Subcutaneous injectionFilgrastim 5 microg/kg/day; alpha-tocopherol succinate 400…Alpha-tocopherol succinate given 1 day before irradiation; filgrastim started 1…
Model: Gastrointestinal acute radiation syndrome induced by 10 Gy whole-body gamma irradiation
Alpha-tocopherol succinate alone reduced malondialdehyde and normalised glutathione, whereas filgrastim alone did not affect these oxidative markers; both lowered myeloperoxidase and IL-1beta. The combination markedly increased glutathione, raised serum citrulline by 94%, reduced epithelial damage…
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