Neuroprotective effects of a potent bradykinin B2 receptor antagonist HOE-140 on microvascular permeability, blood flow disturbances, edema formation, cell injury and nitric oxide synthase upregulation following trauma to the spinal cord.
RatSpinal cord injuryHemisection / partialMaleIntravenous0.1 mg/kg to 1 mg/kg was neuroprotective; 2 mg/kg to 5 mg/k…Pretreatment 30 min before spinal cord injury
Model: Focal incisional spinal cord injury made by a longitudinal incision 2 mm deep and 5 mm long into the right dorsal horn of the T10-11 segment under Equithesin anaesthesia, with a 5 h survival period
Spinal cord injury disrupted the blood-spinal cord barrier, reduced spinal cord blood flow by about 30%, and caused oedema, neuronal damage and neuronal nitric oxide synthase upregulation, including in remote C4 and T5 segments. Pretreatment with low-dose HOE-140 (0.1 to 1 mg/kg intravenously) impr…
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