Self-administered SC icatibant for acute HAE attacks
Hereditary Angioedema
Enrolment: 19 · Results not recorded
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Drug · Bradykinin B2 receptor antagonist (ANTAGONIST)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Hereditary Angioedema
Enrolment: 19 · Results not recorded
Cardiopulmonary Bypass
Enrolment: 150 · Results not recorded
Hereditary Angioedema
Enrolment: 98 · Results not recorded
Angiotensin Converting Enzyme Inhibitor Induced Angioedema
Enrolment: 118 · Results not recorded
COVID-19 Pneumonia
Enrolment: 73 · Results not recorded
Ischaemic Heart Diseases
Enrolment: 12 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Surgical incision involving skin, fascia and muscle (postincisional inflammatory pain model, used as a proxy for burn pain)
HOE 140 at 1, 3 and 10 micrograms significantly relieved mechanical allodynia and guarding compared with vehicle. The effect was locally mediated, and wound healing was normal.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Focal incisional spinal cord injury made by a longitudinal incision 2 mm deep and 5 mm long into the right dorsal horn of the T10-11 segment under Equithesin anaesthesia, with a 5 h survival period
Spinal cord injury disrupted the blood-spinal cord barrier, reduced spinal cord blood flow by about 30%, and caused oedema, neuronal damage and neuronal nitric oxide synthase upregulation, including in remote C4 and T5 segments. Pretreatment with low-dose HOE-140 (0.1 to 1 mg/kg intravenously) impr…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.