Additional effects of erythropoietin pretreatment, ischemic preconditioning, and N-acetylcysteine posttreatment in rat kidney reperfusion injury.
RatIschaemia-reperfusionRenalMale albino WistarMalen = 30 rats allocated to 6 groups of n = 5 (the methods describ…Intraperitoneal for erythropoietin and N-acetylcysteine; surgical clamping for ischaemic preconditioningErythropoietin 1000 IU/kg; N-acetylcysteine 150 mg/kg; isch…Erythropoietin given for 3 days before ischaemia with injury induced on day 4;…
Model: Bilateral renal pedicle occlusion for 50 min followed by 3 days of reperfusion
Each of erythropoietin, ischaemic preconditioning and N-acetylcysteine alone improved renal function, reduced tubular injury, lessened oxidative stress and lowered plasma TNF-alpha and IL-6 compared with untreated ischaemia/reperfusion. The triple combination gave significantly greater protection t…
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