Assessment of the Effectiveness of Quercetin on Cisplatin-Induced Ototoxicity in Rats.
RatChemical/toxinWistar albinoFemale
Model: Cisplatin-induced ototoxicity assessed by otoacoustic emissions and cochlear light microscopy
Cisplatin alone produced significant otoacoustic emission decline, most marked at higher frequencies. Quercetin alone caused no cochlear change. Cochlear damage in the cisplatin plus quercetin group was less severe than with cisplatin alone, indicating a protective effect.
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