QUICKENED: Quercetin for Cardio-Skeletal Muscle Health & Estrogen Deficiency
Menopause Related Conditions
Enrolment: 0 · Results not recorded
Loading the evidence…
Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Menopause Related Conditions
Enrolment: 0 · Results not recorded
Post Operative Pain · Cesarean Section Complications
Enrolment: 80 · Results not recorded
Head and Neck Squamous Cell Carcinomas
Enrolment: 24 · Results not recorded
Aging · Cognitive Decline
Enrolment: 23 · Results not recorded
Gastroesophageal Reflux Disease · GERD
Enrolment: 26 · Results not recorded
SARS (Severe Acute Respiratory Syndrome)
Enrolment: 200 · Results not recorded
10 studies reported at therapy level; 10 evidence entries itemised.
Model: Cisplatin (10 mg/kg i.p.)-induced acute kidney injury
Oral quercetin suppressed indoxyl sulfate accumulation and alleviated cisplatin-induced acute kidney injury.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Cisplatin-induced ototoxicity assessed by otoacoustic emissions and cochlear light microscopy
Cisplatin alone produced significant otoacoustic emission decline, most marked at higher frequencies. Quercetin alone caused no cochlear change. Cochlear damage in the cisplatin plus quercetin group was less severe than with cisplatin alone, indicating a protective effect.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Spinal cord injury at T10 produced by the modified Allen weight-drop method following laminectomy
Quercetin improved locomotor and electrophysiological recovery, reduced cavity formation, and promoted astrocyte activation and axonal regeneration after acute spinal cord injury, with increased BDNF and reduced phosphorylated JNK2 and STAT3.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Superior mesenteric artery occlusion for 1 h followed by reperfusion for 1, 4 or 24 h
Quercetin significantly reduced the mucosal injury index at 4 h of reperfusion together with lower COX-2 expression in villous epithelium, and lowered myeloperoxidase-positive cell numbers in the lamina propria in both acute and late phases, with a significant reduction at 24 h.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Weight-drop impact acceleration model of acute severe traumatic brain injury; weight-drop height and mass not stated
Both quercetin and mannitol lowered malondialdehyde and raised catalase and glutathione peroxidase relative to untreated injury; mannitol significantly reduced serum erythropoietin and 4 hour haematocrit whereas quercetin did not.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Indomethacin-induced acute gastric ulcer, 30 mg/kg orally by orogastric gavage on two consecutive days
Quercetin at 50 mg/kg raised antioxidant enzyme activities and reduced congestion, erosion and necrosis of the gastric mucosa after indomethacin, and was reported to protect better than famotidine.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Acute liver injury induced by intraperitoneal carbon tetrachloride dissolved in olive oil, with sacrifice 24 hours later
Oral quercetin given after carbon tetrachloride lowered serum ALT and AST at 80 mg/kg, improved histology, reduced malondialdehyde and 4-hydroxynonenal, normalised glutathione and reversed the fall in antioxidant gene expression.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Acute myocardial toxicity induced by subcutaneous isoprenaline (isoproterenol) 100 mg/kg
Quercetin did not protect against isoprenaline-induced falls in stroke volume, troponin T release, QRS-T junction elevation or histological damage; the only positive effect was normalisation of raised left ventricular end-diastolic pressure.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Single fraction X-irradiation of the right hind leg with the body lead shielded, 35 Gy at 300 kVp and 1.9 Gy/min; separate SCC-VII tumour arm irradiated at 10 Gy; in vitro clonogenic assays at 2 Gy
Dietary 1 per cent quercetin significantly reduced radiation-induced hind limb contracture at 120 and 150 days and lowered dermal collagen and TGF-beta in irradiated skin, without affecting chow intake, body weight or the acute skin reaction. Quercetin gave no radioprotection of fibroblasts in clon…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Acute spinal cord injury by a modified Allen's weight-drop method
Quercetin improved BBB and inclined plane scores, inhibited p38MAPK phosphorylation and iNOS expression, reduced malondialdehyde and increased superoxide dismutase activity.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.