Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, "M-type") K currents in neurons.
MouseTBIControlled cortical impactC57BL/6Systemic administration30 min after traumatic brain injury
Model: Controlled closed-cortical impact blunt traumatic brain injury
Systemic retigabine given 30 min after injury reduced the post-injury cascade including spontaneous seizures, chemo-convulsant susceptibility, metabolic stress, inflammation, blood-brain barrier breakdown and cell death.
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