A Single Injection of Docosahexaenoic Acid Induces a Pro-Resolving Lipid Mediator Profile in the Injured Tissue and a Long-Lasting Reduction in Neurological Deficit after Traumatic Brain Injury in Mice.
MouseTBIControlled cortical impactIntravenous500 nmol/kg30 min after injury
Model: Controlled cortical impact traumatic brain injury
A single intravenous bolus of docosahexaenoic acid at 30 min post-injury significantly reduced neurological deficit for up to 28 days, raised pro-resolving mediators in the injured hemisphere, reduced lesion size, microglial and astrocytic reaction, oxidation and beta-amyloid precursor protein accu…
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