Vitamin D protects against oxidative stress, inflammation and hepatorenal damage induced by acute paracetamol toxicity in rat.
RatChemical/toxinMalen = 32 male rats distributed equally into four groupsIntraperitoneal injectionProphylactic 1000 IU/kg/day; therapeutic 3000 IU/kg/dayProphylactic group dosed before and again after paracetamol; therapeutic group…
Model: Single oral dose of paracetamol (acetaminophen) 1200 mg/kg causing hepatorenal injury
Both vitamin D regimens alleviated paracetamol-induced hepatorenal damage, restored 25-hydroxyvitamin D and vitamin D pathway gene expression, lowered malondialdehyde and pro-inflammatory cytokines and raised antioxidant and anti-inflammatory markers; the prophylactic protocol outperformed the ther…
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