Assessing therapeutic response non-invasively in a neonatal rat model of acute inflammatory white matter injury using high-field MRI.
RatEndotoxin/LPSSprague-DawleyMale and femaleSystemicGiven with intracerebral lipopolysaccharide at postnatal day 3, assessed 24 h l…
Model: Intracerebral lipopolysaccharide injection causing diffuse inflammatory white matter injury
Multimodal MRI, and diffusion tensor imaging in particular, detected an early neuroprotective effect of IL-1Ra 24 h after treatment, corroborated by immunohistochemistry and inflammatory and cell death mRNA expression.
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