Docosahexaenoic acid decreased neuroinflammation in rat pups after controlled cortical impact.
RatTBIControlled cortical impactSprague-DawleyMaleIntraperitoneal injection followed by dietary supplementationImmediately after controlled cortical impact or sham surgery
Model: Controlled cortical impact traumatic brain injury in the developing brain
Docosahexaenoic acid lowered oxidative stress at day 1 and pro-inflammatory microglial activation at day 3, blunted interferon regulatory factor and pro-inflammatory gene induction in microglia-enriched populations, and improved novel object recognition at day 14.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.