Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences.
MouseTBIControlled cortical impactC57BL/6MaleIntraperitoneal50 mg/kg1 h before traumatic brain injury or sham surgery
Model: Moderate controlled impact traumatic brain injury in the paediatric mouse
Glycyrrhizin lowered brain HMGB1 and oedema at 3 days and prevented short-term spatial memory and motor learning deficits and apparent hippocampal microglial reactivity, but did not reduce evoked seizure severity, the proportion of animals with chronic spontaneous seizures, or cortical tissue loss.
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