Nutraceutical
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Traumatic Teeth · Necrotic Teeth
Enrolment: 45 · Results not recorded
Papilloma Viral Infection · CIN1 · LSIL
Enrolment: 120 · Results not recorded
Intracanal Medication
Enrolment: 36 · Results not recorded
Large B-cell Lymphoma Receiving CAR-T Cell Therapy
Enrolment: 21 · Results not recorded
Hepatocellular Carcinoma
Enrolment: 200 · Results not recorded
6 studies reported at therapy level; 6 evidence entries itemised.
Model: Intracerebral haemorrhage (type IV collagenase injection into striatum); thrombin slice cultures
Glycyrrhizin, an HMGB1 inhibitor, attenuated brain oedema, neuronal loss and behavioural deficits after intracerebral haemorrhage in rats.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: 7 Gy gamma irradiation producing gastrointestinal acute radiation syndrome with gut bacteria-associated sepsis
Glycyrrhizin completely controlled mortality in mice exposed to 7 Gy, minimised bacterial translocation and subsequent sepsis, and prevented M2b macrophage polarisation in mesenteric lymph node macrophages.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Moderate controlled impact traumatic brain injury in the paediatric mouse
Glycyrrhizin lowered brain HMGB1 and oedema at 3 days and prevented short-term spatial memory and motor learning deficits and apparent hippocampal microglial reactivity, but did not reduce evoked seizure severity, the proportion of animals with chronic spontaneous seizures, or cortical tissue loss.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Total parenteral nutrition-associated acute liver injury induced by intravenous Kabiven infusion at 20 mL/kg/h for 3 h under urethane anaesthesia (1 g/kg intraperitoneally)
Glycyrrhizin pretreatment dose-dependently normalised AST, ALT, total bilirubin and triglyceride, restored normal hepatocyte counts (zone 1: 310 +/- 18 at 10 mg/kg vs 204 +/- 14 with total parenteral nutrition alone and 408 +/- 12 in controls), reduced cleaved caspase-3 positive hepatocytes and low…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Acute glaucoma modelled by anterior chamber cannulation of the right eye with a 30-gauge needle and Balanced Salt Solution infusion raising intraocular pressure to 70 mmHg for 60 min, producing retinal ischaemia-reperfusion injury and retinal ganglion cell death; left eye served as control
HMGB1 rose in ischaemic retina from 6 h and peaked at 48 h. Exogenous recombinant HMGB1 worsened retinal thinning and retinal ganglion cell loss and increased cleaved caspase-8, NLRP3, ASC, caspase-1 processing, phospho-NF-kappaB p65 and IL-1beta, whereas the HMGB1 inhibitor glycyrrhizic acid reduc…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Intratracheal instillation of benzo(a)pyrene causing acute lung injury
Glycyrrhizic acid suppressed caspase activities in lung tissue, lowered lavage total protein, cell counts, elastase, lactate dehydrogenase and alkaline phosphatase, restored phospholipid content and improved histology after benzo(a)pyrene exposure.
Extraction: extract · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.
