Innovative mouse model mimicking human-like features of spinal cord injury: efficacy of Docosahexaenoic acid on acute and chronic phases.
MouseSpinal cord injuryContusionCD1Femalen = Behaviour n = 8 to 11 per group; immunohistochemistry n = 3…Intraperitoneal0.082 mg/kgFirst dose within 1 hour of surgery
Model: Severe contusion spinal cord injury at thoracic level T10 without laminectomy, delivered with a stereotaxic frame and computer-controlled PinPoint precision impactor (tip #4, velocity 3 m/s, depth 5 mm, dwell time 800 ms)
DHA restored hindlimb locomotor function and the tail-flick reflex in mice that were otherwise permanently paraplegic, reduced gliosis, cavitation and microglial activation, lowered caspase-3, p75NTR and pJNK, and increased regenerated area at 60 days.
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