Modulatory effects of vitamin C on biochemical and oxidative changes induced by acute exposure to diazinon in rat various tissues: Prophylactic and therapeutic roles.
RatChemical/toxinWistarMalen = 30 male Wistar rats divided into five groups200 mg/kgOne group dosed before and one group after diazinon injection
Model: Acute diazinon (organophosphate) exposure at 100 mg/kg causing multi-tissue oxidative injury
Diazinon raised superoxide dismutase, glutathione-S-transferase and malondialdehyde and lowered cholinesterase, lactate dehydrogenase and glutathione; both prophylactic and therapeutic vitamin C ameliorated these changes, most notably in brain tissue, although values did not return to normal.
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