Induction of Nrf2 pathway by Dendrobium nobile Lindl. alkaloids protects against carbon tetrachloride induced acute liver injury.
MouseChemical/toxinC57BL/6 wild-type and Nrf2-knockoutMaleIntragastric20 mg/kg/dayPre-treatment for 7 days before carbon tetrachloride challenge
Model: Carbon tetrachloride 20 microlitres/kg intraperitoneal acute liver injury
DNLA reduced carbon tetrachloride-induced liver injury in wild-type mice, lowering transaminases and malondialdehyde and improving hepatocyte ultrastructure, with the protection lost in Nrf2-knockout mice, indicating an Nrf2-dependent mechanism.
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