THERAPY DOSSIER · th-c4535ea36957

Dendrobium nobile Lindl. alkaloids (DNLA)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31212129 ↗2019Reported benefit

Induction of Nrf2 pathway by Dendrobium nobile Lindl. alkaloids protects against carbon tetrachloride induced acute liver injury.

MouseChemical/toxinC57BL/6 wild-type and Nrf2-knockoutMaleIntragastric20 mg/kg/dayPre-treatment for 7 days before carbon tetrachloride challenge

Model: Carbon tetrachloride 20 microlitres/kg intraperitoneal acute liver injury

DNLA reduced carbon tetrachloride-induced liver injury in wild-type mice, lowering transaminases and malondialdehyde and improving hepatocyte ultrastructure, with the protection lost in Nrf2-knockout mice, indicating an Nrf2-dependent mechanism.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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