STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
MouseTBIWeight-drop / impact-accelerationC57BL/6MalePre-administration before injuryEthanol given before traumatic brain injury; outcomes at 3 h and 7 days
Model: Blunt weight-drop traumatic brain injury with simulated ethanol intoxication
Ethanol intoxication downregulated injury-induced IL-33, IL-1beta, IL-38, TNF-alpha and IL-19 and upregulated IL-13 and IL-12, reduced microglial activation and astrogliosis and preserved synaptic density and baseline neuronal activity at 7 days; STAT6 inhibition reversed these effects and negated…
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