Hydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyBoth sexesInhalationFollowing induction of hypoxia-ischaemia
Model: Neonatal hypoxic-ischaemic brain damage induced surgically in postnatal day 7 rats
Hydrogen inhalation attenuated the microglial inflammatory response, neuronal damage and apoptotic marker expression, and ameliorated long-term spatial memory deficits, with greater effect at longer inhalation durations.
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