Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion · Radiation
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyBoth sexesInhalationFollowing induction of hypoxia-ischaemia
Model: Neonatal hypoxic-ischaemic brain damage induced surgically in postnatal day 7 rats
Hydrogen inhalation attenuated the microglial inflammatory response, neuronal damage and apoptotic marker expression, and ameliorated long-term spatial memory deficits, with greater effect at longer inhalation durations.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
RatRadiationSprague-DawleyMaleSubcutaneous injectionBefore irradiation
Model: Local single-dose or fractionated irradiation of the head and neck area (single 15, 20 or 25 Gy, or a cumulative 30 Gy in three fractions)
Hydrogen reduced dermatitis severity, accelerated tissue recovery and limited weight loss after single doses of 15 or 20 Gy and after 30 Gy in three fractions, but not after a single 25 Gy dose, and protected HaCaT cells in vitro.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
