Assessment of the Antiangiogenic and Anti-Inflammatory Properties of a Maslinic Acid Derivative and its Potentiation using Zinc Chloride
MouseChemical/toxinSKH1 hairless mice; fertilised hen eggs for the chorioallantoic membrane assayFemaleTopical application of hydrogel to the ear; topical application onto the chorioallantoic membrane inside a plastic ringEM2 1% hydrogel; zinc chloride 1% and 5% hydrogels; EM2 1%…30 min after topical application of the TPA solution
Model: Acute ear inflammation induced by topical application of 20 ul per ear of 15 nM 12-O-tetradecanoylphorbol-13-acetate in acetone under sevoflurane anaesthesia; separately, the chick chorioallantoic membrane assay from embryonic day 8 to day 12 to assess tolerability and normal angiogenesis
EM2 1% hydrogel produced only a mild reduction in TPA-induced ear oedema and inflammatory infiltrate, with neutrophils diffusely distributed, moderate interstitial oedema and mast cell numbers similar to control. Zinc chloride hydrogels alone gave a mild reduction at 1% and a moderate anti-inflamma…
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