THERAPY DOSSIER · th-e78c2a364abb

Benzyl (2alpha,3beta) 2,3-diacetoxy-olean-12-en-28-amide (EM2), a benzylamide derivative of maslinic acid, alone or associated with zinc chloride

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06484543 ↗NAactive not recruiting

Brown Fat as Therapeutic Strategy for Obesity and Associated Metabolic Diseases Via Functional/Nutraceutical Approach - Molecular Mechanisms of Pentacyclic Triterpenes (BRACE), maslinic acid

Diabetes · Brown Adipose Tissue

Enrolment: 50 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31185643 ↗2019Reported benefit

Assessment of the Antiangiogenic and Anti-Inflammatory Properties of a Maslinic Acid Derivative and its Potentiation using Zinc Chloride

MouseChemical/toxinSKH1 hairless mice; fertilised hen eggs for the chorioallantoic membrane assayFemaleTopical application of hydrogel to the ear; topical application onto the chorioallantoic membrane inside a plastic ringEM2 1% hydrogel; zinc chloride 1% and 5% hydrogels; EM2 1%…30 min after topical application of the TPA solution

Model: Acute ear inflammation induced by topical application of 20 ul per ear of 15 nM 12-O-tetradecanoylphorbol-13-acetate in acetone under sevoflurane anaesthesia; separately, the chick chorioallantoic membrane assay from embryonic day 8 to day 12 to assess tolerability and normal angiogenesis

EM2 1% hydrogel produced only a mild reduction in TPA-induced ear oedema and inflammatory infiltrate, with neutrophils diffusely distributed, moderate interstitial oedema and mast cell numbers similar to control. Zinc chloride hydrogels alone gave a mild reduction at 1% and a moderate anti-inflamma…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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