Enhanced descending pain facilitation in acute traumatic brain injury
RatTBIFluid percussionSprague DawleyMaleIntrathecal injection at the lumbar L5-L6 interspace for 5,7-dihydroxytryptamine and ondansetron; intraperitoneal for desipramine5,7-dihydroxytryptamine 60 ug in 20 ul; ondansetron 20 ug i…5,7-dihydroxytryptamine given at 3 days post-injury, with behavioural testing r…
Model: Lateral fluid percussion traumatic brain injury under isoflurane anaesthesia, with a 5 mm craniotomy midway between bregma and lambda approximately 2 mm right of the midline and a pressure wave of 1.3 +/- 0.1 atm producing a mild injury; sham rats received the same procedure with no pressure wave
Traumatic brain injury caused significant mechanical allodynia in the contralateral hindpaw by 3 days post-injury lasting about 3 weeks, with less marked ipsilateral sensitisation. Intrathecal 5,7-dihydroxytryptamine given at 3 days post-injury significantly reduced sensitisation, and withdrawal th…
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