Acute and chronic effects of single dose memantine after controlled cortical impact injury in adult rats.
RatTBIControlled cortical impactMaleIntraperitoneal2.5, 5 or 10 mg/kg, with only 10 mg/kg effective1 hour after injury
Model: Moderate to severe controlled cortical impact traumatic brain injury
Memantine at 10 mg/kg preserved cortical tissue and reduced neuronal degeneration at 1 day and attenuated hippocampal synaptophysin loss at 7 days, but had no effect on histopathology at 21 and 90 days and no effect on vestibulomotor function or spatial memory acquisition, with only a trend towards…
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