Efficacy of Memantine Hydrochloride and Escitalopram for Co-Morbid Depression and Alcoholism
Alcoholism · Depression
Enrolment: 80 · Results not recorded
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Drug · Glutamate [NMDA] receptor negative allosteric modulator (NEGATIVE ALLOSTERIC MODULATOR, direct interaction, disease efficacy true)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Alcoholism · Depression
Enrolment: 80 · Results not recorded
PTSD
Enrolment: 26 · Results not recorded
Alzheimer's Disease
Enrolment: 206 · Results not recorded
Substance Abuse
Enrolment: 200 · Results not recorded
Alzheimer Disease
Enrolment: 90 · Results not recorded
Alcohol Drinking
Enrolment: 111 · Results not recorded
Neuropathic Pain
Enrolment: 7 · Results not recorded
Autism Spectrum Disorder
Enrolment: 747 · Results not recorded
Malignant Central Nervous System Neoplasm
Enrolment: 18 · Results not recorded
5 studies reported at therapy level; 7 evidence entries itemised.
Model: Moderate to severe controlled cortical impact traumatic brain injury
Memantine at 10 mg/kg preserved cortical tissue and reduced neuronal degeneration at 1 day and attenuated hippocampal synaptophysin loss at 7 days, but had no effect on histopathology at 21 and 90 days and no effect on vestibulomotor function or spatial memory acquisition, with only a trend towards…
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Model: Fluid percussion traumatic brain injury under anaesthesia
Memantine significantly attenuated injury-induced motor and proprioceptive deficits and infarction volume, and reduced neuronal apoptosis, astrogliosis, microgliosis, neuronal nitric oxide synthase and 3-nitro-L-tyrosine positive neurons and inducible nitric oxide synthase in microglia and astrocyt…
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Model: Whole-brain radiotherapy in Thy-1-YFP mice and irradiation of hippocampal cultures expressing enhanced green fluorescent protein; radiation dose and fractionation not stated in the retrieved text
Irradiation produced an acute increase in dendritic spines and excitatory synapses followed by a later decrease in spine and synapse density with altered spine dynamics. Memantine pre-administration prevented this radiation-induced synaptic remodelling. The authors interpret this as evidence that a…
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Model: Repetitive mild closed head injury, 54 g metal bolt dropped from 71 cm onto the head under a guide tube centred over bregma, once daily for 4 consecutive days
Memantine reduced acute tau phosphorylation, glial activation and long-term potentiation deficits at one month and normalised NMDA receptor expression, but did not produce corresponding improvements in behavioural outcomes.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Lateral fluid percussion traumatic brain injury
The memantine plus 17beta-estradiol combination increased neuronal survival, reduced neuronal degeneration in ipsilateral hippocampus and cortex, improved vestibulomotor deficits and modestly reduced anxiety.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
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Extraction: mesh. Machine-extracted fields require source verification.