Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice.

Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice.

Model: Acute inflammation by intradermal sub-plantar injection of 100 microlitres of 1% lambda-carrageenan in saline into the left hind paw of rats, and chronic colitis by intracolonic administration of 100 microlitres of 2.5% TNBS in 50% ethanol in mice

Spearmint extract reduced carrageenan-induced paw oedema by 36% (24 +/- 16% versus 60 +/- 20% in the carrageenan group, p < 0.01), with an effect similar to indomethacin, trolox and tempol. In TNBS colitis it produced shorter and less severe lesions, a histological score of about 1 with some areas…

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