Topical tranexamic acid inhibits fibrinolysis more effectively when formulated with self-propelling particles.
MouseHaemorrhage/shockUncontrolledC57BL/6 inbred mice; Sus scrofa swinen = Six pigs in the treated arteriotomy group (four of six surv…Topical to the wound site, including incorporation into gauze; subcutaneous for tolerability testingSubcutaneous tolerability in mice demonstrated up to 300 to…After injury, applied to the wound site; pigs treated after femoral arteriotomy
Model: Murine tail bleeding assay; swine junctional haemorrhage by femoral arteriotomy without compression; in vitro clot lysis assays
Self-propelled tranexamic acid was more effective than non-propelled formulations at stabilising clots from lysis in vitro and at reducing blood loss in mice. When incorporated into gauze, four of six pigs treated after femoral arteriotomy without compression survived, and systemic tranexamic acid…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.