Neuroendocrine Whiplash: Slamming the Breaks on Anabolic-Androgenic Steroids Following Repetitive Mild Traumatic Brain Injury in Rats May Worsen Outcomes.
RatTBIControlled cortical impactSprague Dawley (Charles River Laboratories)Malen = 47 male Sprague Dawley rats across four groups of n equals…Oral, dissolved in the drinking water1.5 mg/kg body weight per dayCommenced at postnatal day 21, twenty days before the first mild traumatic brai…
Model: Repetitive mild traumatic brain injury, three impacts delivered with the lateral impact device using a 50 g weight fired at an average 8.95 plus or minus 0.12 m/s producing 81.66 G, with a helmet preventing skull damage and driving a horizontal 180 degree rotation
Repetitive mild traumatic brain injury increased time-to-right, beam walk foot slips and anxiety-like behaviour and impaired short-term working memory. Steroid and exercise cessation produced hyperactivity in the open field and greater weight gain, and interacted with injury so that injured rats th…
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