Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model.
MouseEndotoxin/LPSICRFemale (pregnant dams); offspring sex not statedMaternal administration; specific route not stated in the abstractPre-treatment, given to the dam before lipopolysaccharide challenge
Model: Lipopolysaccharide-induced maternal inflammation in pregnant mice causing preterm birth and perinatal fetal brain injury
Melatonin pre-treatment lowered proinflammatory cytokines in the uterus and placenta, significantly improved lipopolysaccharide-induced acute fetal neuroinflammation and perinatal brain injury, and significantly upregulated SIRT1/Nrf2 signalling. It decreased preterm birth and prevented adverse neu…
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