Protective effects of maresin 1 against inflammation in experimentally induced acute pancreatitis and related lung injury.
MouseChemical/toxinC57BL/6MaleAdministered 30 min before the primary injection of caerulein, that is as pretr…
Model: Severe acute pancreatitis with related lung injury induced by a combination of caerulein and lipopolysaccharide
Maresin 1 pretreatment reduced serum amylase, lipase, TNF-alpha, IL-1beta and IL-6, lowered myeloperoxidase activity in pancreas and lung, increased serum IL-10, reduced pancreatic NF-kappaB activation and lessened the severity of pancreatic and lung injury.
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