Effect of Hydrotalcite on Indometacin-Induced Gastric Injury in Rats.
RatChemical/toxinWistarbothn = 100 Wistar rats in total; 50 rats per experiment (25 male,…oral gavagePreventive experiment: pretreatment 0.5 h before indometacin. Curative experime…
Model: Indometacin-induced acute gastric mucosal injury, single dose of indometacin 30 mg/kg by gavage after 24 h food starvation
Hydrotalcite reduced the gastric lesion index in both preventive and curative experiments (7 +/- 4.5 versus 16 +/- 11.25 and 1.5 +/- 2 versus 2.5 +/- 6) and raised serum EGF and PGE2 and mucosal COX-2 relative to the model group.
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