Single dose oral Talcid (1000 mg hydrotalcite) versus famotidine 10 mg versus placebo in acute heartburn
Heartburn
Enrolment: 559 · Results not recorded
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Drug · No ChEMBL mechanism record. ATC A02AD04 (antacid; combinations and complexes of aluminium, calcium and magnesium compounds). Parent entity CHEMBL3833409.
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Heartburn
Enrolment: 559 · Results not recorded
NSAID-associated Intestinal Mucosal Injury
Enrolment: 100 · Results not recorded
Dyspepsia
Enrolment: 300 · Results not recorded
Dyspepsia
Enrolment: 286 · Results not recorded
Chronic Atrophic Gastritis
Enrolment: 468 · Results not recorded
Chronic Atrophic Gastritis
Enrolment: 60 · Results not recorded
Gastroesophageal Reflux
Enrolment: 167 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Indometacin-induced acute gastric mucosal injury, single dose of indometacin 30 mg/kg by gavage after 24 h food starvation
Hydrotalcite reduced the gastric lesion index in both preventive and curative experiments (7 +/- 4.5 versus 16 +/- 11.25 and 1.5 +/- 2 versus 2.5 +/- 6) and raised serum EGF and PGE2 and mucosal COX-2 relative to the model group.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.