Characterizing the Neuroprotective Effects of S/B Remedy (Georgi andWilld) in Spinal Cord Injury.
RatSpinal cord injuryContusionSprague-Dawleyfemaleintraperitoneal2 or 20 mg/kg, then 2 or 20 mg/kg/dayFirst dose 30 min before injury; a separate group received 20 mg/kg starting af…
Model: Severe contusive spinal cord injury using the NYU weight-drop device, 10 g rod dropped from 50 mm onto the T9-T10 dorsal cord after T9 laminectomy
S/B at 20 mg/kg improved BBB hindlimb scores to 5 weeks and reduced ED-1 expression and spinal lactate, with a non-significant trend to preserved neurofilament-L and reduced malondialdehyde, whereas 2 mg/kg had no effect.
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