THERAPY DOSSIER · th-dbcbf9dc042e

S/B remedy, hot-water extract of Scutellaria baicalensis and Bupleurum (7:3), a simplified Sho-Saiko-To formula

Nutraceutical · S/B remedy, hot-water extract of Scutellaria baicalensis and Bupleurum (simplified Sho-Saiko-To); herbal formula.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: S/B remedy, hot-water extract of Scutellaria baicalensis and Bupleurum (simplified Sho-Saiko-To); herbal formula.
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31100896 ↗2019Reported benefit

Characterizing the Neuroprotective Effects of S/B Remedy (Georgi andWilld) in Spinal Cord Injury.

RatSpinal cord injuryContusionSprague-Dawleyfemaleintraperitoneal2 or 20 mg/kg, then 2 or 20 mg/kg/dayFirst dose 30 min before injury; a separate group received 20 mg/kg starting af…

Model: Severe contusive spinal cord injury using the NYU weight-drop device, 10 g rod dropped from 50 mm onto the T9-T10 dorsal cord after T9 laminectomy

S/B at 20 mg/kg improved BBB hindlimb scores to 5 weeks and reduced ED-1 expression and spinal lactate, with a non-significant trend to preserved neurofilament-L and reduced malondialdehyde, whereas 2 mg/kg had no effect.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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