Modulation of Serotonin and Adenosine 2A Receptors on Intermittent Hypoxia-Induced Respiratory Recovery following Mid-Cervical Contusion in the Rat.
RatSpinal cord injuryContusionSprague-DawleyMaleInhalation10 episodes of 5 min hypoxia (10% O2, 4% CO2, 86% N2) alter…Acute (about 3 days), subchronic (about 2 weeks) and chronic (about 8 weeks) po…
Model: Unilateral contusion of the C3-C4 spinal cord; laminectomy controls
Acute intermittent hypercapnic-hypoxia increased minute ventilation via augmented tidal volume in contused rats at all post-injury stages, although ventilatory long-term facilitation occurred only in uninjured animals at the acute stage. The response was attenuated by methysergide and enhanced by K…
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