THERAPY DOSSIER · th-84ad9bf0d01c

Acute intermittent hypercapnic-hypoxia

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07002437 ↗Injury indicationNArecruiting

Intermittent Hypoxia-Induced Motor Plasticity in Sub-Acute Spinal Cord Injury

Spinal Cord Injuries (SCI)

Enrolment: 18 · Results not recorded

NCT06011876 ↗Injury indicationNArecruiting

Genetic Biomarkers of Intermittent Hypoxia-Induced Respiratory Motor Plasticity in Chronic SCI

Spinal Cord Injuries

Enrolment: 62 · Results not recorded

NCT06101199 ↗Injury indicationNAterminated

Effect of Single Session Combined Acute Intermittent Hypercapnic-Hypoxia and Transcutaneous Spinal Stimulation on Cervical Neural Drive in Chronic Spinal Cord Injury

Cervical Spinal Cord Injury

Enrolment: 4 · Results not recorded

NCT07135583 ↗Injury indicationNArecruiting

Non-Invasive Interventions and Biomarker Identification for Respiratory Recovery in Chronic Spinal Cord Injury

Spinal Cord Injury, Chronic

Enrolment: 20 · Results not recorded

NCT07674264 ↗NArecruiting

A Pilot Study of Acute Intermittent Hypercapnia-Based Interventions on Upper Airway and Axial Motor Function in Parkinson's Disease

Parkinson Disease · Parkinsonism

Enrolment: 32 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31099299 ↗2019Reported benefit

Modulation of Serotonin and Adenosine 2A Receptors on Intermittent Hypoxia-Induced Respiratory Recovery following Mid-Cervical Contusion in the Rat.

RatSpinal cord injuryContusionSprague-DawleyMaleInhalation10 episodes of 5 min hypoxia (10% O2, 4% CO2, 86% N2) alter…Acute (about 3 days), subchronic (about 2 weeks) and chronic (about 8 weeks) po…

Model: Unilateral contusion of the C3-C4 spinal cord; laminectomy controls

Acute intermittent hypercapnic-hypoxia increased minute ventilation via augmented tidal volume in contused rats at all post-injury stages, although ventilatory long-term facilitation occurred only in uninjured animals at the acute stage. The response was attenuated by methysergide and enhanced by K…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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