Hesperidin, a citrus flavanone glycoside, accelerates the gastric healing process of acetic acid-induced ulcer in rats.
RatChemical/toxinWistarOral (p.o.)1 to 10 mg/kg, with significant healing at 3 and 10 mg/kgAfter ulcer induction
Model: Chronic gastric ulcer induced by acetic acid
Hesperidin at 3 and 10 mg/kg accelerated ulcer healing by 34% and 62% respectively relative to vehicle (99.1 +/- 6.4 mm2), increased mucin production, preserved glutathione, normalised superoxide dismutase and catalase, increased glutathione-S-transferase activity by 35%, and reduced lipoperoxides…
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